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Page 1
Did you mean acac and acly (1 results)?
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).
Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD. Sharma RS, et al. Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar. Cell Mol Gastroenterol Hepatol. 2017. PMID: 29552625 Free PMC article.
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via alpha-ketoglutarate.
Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT. Keenan MM, et al. PLoS Genet. 2015 Oct 9;11(10):e1005599. doi: 10.1371/journal.pgen.1005599. eCollection 2015 Oct. PLoS Genet. 2015. PMID: 26452058 Free PMC article.
We discovered that genetic depletion of acetyl-CoA carboxylase (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis. Additionally, the loss of ACLY or ACC1 reduced levels and activities of the oncogenic transcripti …
We discovered that genetic depletion of acetyl-CoA carboxylase (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer ce …
Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism.
Zhou T, Cao L, Du Y, Qin L, Lu Y, Zhang Q, He Y, Tan D. Zhou T, et al. PeerJ. 2023 Apr 11;11:e15225. doi: 10.7717/peerj.15225. eCollection 2023. PeerJ. 2023. PMID: 37065701 Free PMC article.
Further results showed that GP reduced fatty acid synthesis by downregulating the expression of Srebf1, Fasn, Acss2, Acly, Acaca, Fads1, and Elovl6; modulated glycerolipid metabolism by inducing the expression of Mgll; promoted fatty acid transportation and degradat …
Further results showed that GP reduced fatty acid synthesis by downregulating the expression of Srebf1, Fasn, Acss2, Acly, Acaca …
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress.
Chen M, Zhang R, Chen Y, Chen X, Li Y, Shen J, Yuan M, Chen Y, Wu J, Sun Q. Chen M, et al. Phytomedicine. 2023 Jul 25;116:154902. doi: 10.1016/j.phymed.2023.154902. Epub 2023 May 24. Phytomedicine. 2023. PMID: 37270969
We further showed that NOB reduced de novo fatty acid (FA) synthesis, as evidenced by the decreased levels of neutral lipids and the expression levels of ACLY, ACACA and FASN, and ACLY abrogated the effect of NOB on lipid deposits in GC cells. In addition, we …
We further showed that NOB reduced de novo fatty acid (FA) synthesis, as evidenced by the decreased levels of neutral lipids and the express …
Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis.
McGlone ER, Siebert M, Dore M, Hope DCD, Davies I, Owen B, Khoo B, Goldin R, Carling D, Bloom S, Le Gall M, Tan TM. McGlone ER, et al. Liver Int. 2023 Sep;43(9):1890-1900. doi: 10.1111/liv.15614. Epub 2023 May 19. Liver Int. 2023. PMID: 37208943 Free PMC article.
Genes downstream of glucagon receptor signalling which govern fatty acid synthesis (Acaca, Acacb, Me1, Acly, Fasn and Elovl6) were downregulated following VSG but upregulated in Sham-WM. ...
Genes downstream of glucagon receptor signalling which govern fatty acid synthesis (Acaca, Acacb, Me1, Acly, Fasn and Elovl6) …
Role of Lipogenesis Rewiring in Hepatocellular Carcinoma.
Zhou Y, Tao J, Calvisi DF, Chen X. Zhou Y, et al. Semin Liver Dis. 2022 Feb;42(1):77-86. doi: 10.1055/s-0041-1731709. Epub 2021 Jul 26. Semin Liver Dis. 2022. PMID: 34311471 Free PMC article.
Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes involved in de novo lipogenesis, including ACLY, ACACA, FASN, and SCD. Studies have shown the increased de novo lipogenesis in human hepatocellular carcinom …
Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes involved in de novo lipogenesi …
NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism.
Okada N, Ueki C, Shimazaki M, Tsujimoto G, Kohno S, Muranaka H, Yoshikawa K, Takahashi C. Okada N, et al. Commun Biol. 2023 Jun 2;6(1):596. doi: 10.1038/s42003-023-04987-9. Commun Biol. 2023. PMID: 37268670 Free PMC article.
Here, we demonstrate that NFYAv1, a long-form variant, upregulates the transcription of essential lipogenic enzymes ACACA and FASN to enhance the malignant behavior of triple-negative breast cancer (TNBC). Loss of the NFYAv1-lipogenesis axis strongly suppresses malignant b …
Here, we demonstrate that NFYAv1, a long-form variant, upregulates the transcription of essential lipogenic enzymes ACACA and FASN to …
Sulforaphane downregulated fatty acid synthase and inhibited microtubule-mediated mitophagy leading to apoptosis.
Yan Y, Zhou Y, Li J, Zheng Z, Hu Y, Li L, Wu W. Yan Y, et al. Cell Death Dis. 2021 Oct 7;12(10):917. doi: 10.1038/s41419-021-04198-2. Cell Death Dis. 2021. PMID: 34620841 Free PMC article.
Results showed that SFN depolymerized microtubules, downregulated FASN, and decreased its binding to alpha-tubulin; SFN downregulated FASN, acetyl CoA carboxylase (ACACA), and ATP citrate lyase (ACLY) via activating proteasomes and downregulating transcriptional fac …
Results showed that SFN depolymerized microtubules, downregulated FASN, and decreased its binding to alpha-tubulin; SFN downregulated FASN, …
Central Role for Glycolysis and Fatty Acids in LH-responsive Progesterone Synthesis.
Przygrodzka E, Binderwala F, Powers R, McFee RM, Cupp AS, Wood JR, Davis JS. Przygrodzka E, et al. bioRxiv [Preprint]. 2024 Feb 14:2024.02.14.580329. doi: 10.1101/2024.02.14.580329. bioRxiv. 2024. PMID: 38405789 Free PMC article. Preprint.
Furthermore, LH via the protein kinase A (PKA) pathway triggered post- translational modification of acetyl-CoA carboxylase alpha (ACACA) and ATP citrate lyase (ACLY), enzymes involved in de novo synthesis of fatty acids. Inhibition of ACLY and fatty acid tra …
Furthermore, LH via the protein kinase A (PKA) pathway triggered post- translational modification of acetyl-CoA carboxylase alpha (ACACA …
Differences in Muscle Lipogenic Gene Expression, Carcass Traits and Fat Deposition among Three Iberian Pig Strains Finished in Two Different Feeding Systems.
Garrido N, Izquierdo M, Hernández-García FI, Núñez Y, García-Torres S, Benítez R, Padilla JÁ, Óvilo C. Garrido N, et al. Animals (Basel). 2023 Mar 23;13(7):1138. doi: 10.3390/ani13071138. Animals (Basel). 2023. PMID: 37048394 Free PMC article.
The present study evaluated carcass traits, fat deposition and muscle expression of important lipogenic genes (SCD, ME1, ACACA, FASN, EGR1, ACOX and ACLY) using 65 male pigs of 3 Iberian strains (20 Lampino, 23 Torbiscal, and 22 Retinto) finished either in a convent …
The present study evaluated carcass traits, fat deposition and muscle expression of important lipogenic genes (SCD, ME1, ACACA, FASN, …
41 results